Genome Wide Association Studies (GWAS)

Course Overview

Genome-Wide Association Studies (GWAS) is a powerful approach to uncover genetic variants associated with traits and diseases. This mini workshop will introduce the principles and workflows of GWAS, from data preparation and population structure correction to visualization and interpretation of results. Led by Putut Rakhmad Purnama, M.Si., Ph.D. from Universitas Negeri Surabaya , participants will gain both theoretical understanding and practical experience performing GWAS analysis using real data and open-source tools. Genome-Wide Association Studies (GWAS) is a powerful approach to uncover genetic variants associated with traits and diseases. This mini workshop will introduce the principles and workflows of GWAS, from data preparation and population structure correction to visualization and interpretation of results. Led by Putut Rakhmad Purnama, M.Si., Ph.D. from Universitas Negeri Surabaya , participants will gain both theoretical understanding and practical experience performing GWAS analysis using real data and open-source tools.

Sub-topics

• 1.
  Fundamentals of GWAS: Principles and Concepts, Study Design, Applications across Medicine, Agriculture, and Animal Science

• 2.
  Population Structure and Models: Population Stratification, Single-Locus vs Multi-Locus GWAS, Statistical Considerations

• 3.
  Applications and Future Directions: Linking Variants to Genes and Pathways, Polygenic Risk Scores, Crop and Livestock Breeding

• 4.
  Tools and Resources: Association Testing Methods, Multiple Testing Corrections, Software Platforms (PLINK, GEMMA, TASSEL, GAPIT, mrMLM)

• 5.
  Hands-On GWAS Analysis: Data Preparation and Quality Control, Running GWAS, Visualization and Interpretation of Results"

Course Components

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